Bioactive Small Molecules
A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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2,791
Tocris Bioscience™ BS 181 dihydrochloride
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Selective cdk7 inhibitor
| Target | Cyclin-dependent Kinase Inhibitors |
|---|---|
| CAS | 1883548-83-1 |
| Purity | >99% |
| Chemical Name or Material | N5-(6-Aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine dihydrochloride |
| Recommended Storage | Store at 4°C |
| Molecular Formula | C22H32N6.2HCl |
| Formula Weight | 453.45 |
2,792
Tocris Bioscience™ VTP 27999 trifluoroacetate
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Highly potent and selective renin inhibitor
2,793
Tocris Bioscience™ AC 186
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Potent and selective ERβ agonist; neuroprotective
| Product Type | AC 186 |
|---|---|
| Molecular Weight (g/mol) | 306.32 |
| Purity | >99% |
2,794
Tocris Bioscience™ NGB 2904
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CAS: 189061-11-8 Molecular Formula: C28H30Cl3N3O
| CAS | 189061-11-8 |
|---|---|
| Molecular Formula | C28H30Cl3N3O |
2,795
Tocris Bioscience™ Dihydro-β-erythroidine hydrobromide
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CAS: 29734-68-7 Molecular Formula: C16H22BrNO3
| CAS | 29734-68-7 |
|---|---|
| Molecular Formula | C16H22BrNO3 |
2,796
Tocris Bioscience™ PDD 00017273
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Potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor
2,797
Tocris Bioscience™ TC-S 7004
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Potent and selective DYRK1A/B inhibitor
| Product Type | TC-S 7004 |
|---|---|
| Molecular Weight (g/mol) | 498.32 |
| Purity | >98% |
2,798
Tocris Bioscience™ (±)-Clopidogrel hydrochloride
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CAS: 130209-90-4 Molecular Formula: C16H17Cl2NO2S
| CAS | 130209-90-4 |
|---|---|
| Molecular Formula | C16H17Cl2NO2S |
2,799
Tocris Bioscience™ Sumatriptan succinate
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5-HT1A, 5-HT1B and 5-HT1D agonist
| Inhibitors | Sumatriptan succinate |
|---|---|
| Product Type | Sumatriptan succinate |
| Molecular Weight (g/mol) | 413.49 |
| Purity | >99% |
2,800
Tocris Bioscience™ Thalidomide 4'-oxyacetamide-PEG3-amine
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PROTACs (Proteolysis Targeting Chimeras)
2,801
Tocris Bioscience™ TCS PIM-1 1
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CAS: 491871-58-0 Molecular Formula: C18H11BrN2O2
| CAS | 491871-58-0 |
|---|---|
| Molecular Formula | C18H11BrN2O2 |
2,802
Tocris Bioscience™ Sephin 1
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Inhibitor of the regulatory subunit PPP1R15A of protein phosphatase 1
| Target | Protein Ser/Thr Phosphatase Inhibitors |
|---|---|
| Purity | >98% |
| Chemical Name or Material | (2E)-2-[(2-Chlorophenyl)methylene]-hydrazinecarboximidamide carbonic acid salt |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C8H9ClN4.CH2O3 |
| Formula Weight | 258.66 |
2,803
Tocris Bioscience™ Benzamil
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CAS: 161804-20-2 Molecular Formula: C13H14ClN7O·HCl
| CAS | 161804-20-2 |
|---|---|
| Molecular Formula | C13H14ClN7O·HCl |
2,804
Tocris Bioscience™ OSU 03012
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PDPK1 (PDK1) inhibitor; inhibits Akt signaling
| Target | PDK-1 Inhibitors |
|---|---|
| CAS | 742112-33-0 |
| Purity | >98% |
| Chemical Name or Material | 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C26H19F3N4O |
| Formula Weight | 460.45 |
2,805
Tocris Bioscience™ Bexarotene
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Potent and selective RXR agonist
| Target | Retinoid X Receptor Agonists |
|---|---|
| CAS | 153559-49-0 |
| Purity | >99% |
| Chemical Name or Material | 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid |
| Recommended Storage | Store at 4°C |
| Synonym | LGD 1069 |
| Molecular Formula | C24H28O2 |
| Formula Weight | 348.48 |